Structure of PDB 7b1g Chain A Binding Site BS01

Receptor Information
>7b1g Chain A (length=691) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELSTQEKSYLSAVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIA
IENENLEIIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHFSDFTPDIT
PIILAAHTNNYEIIKMLVQKGVSVPQPHDVDSLRHSRSRLNIYKALASPS
LIALSSEDPFLTAFQLSWELQELSKVENEFKAEYEELSHQCKHFAKDLLD
QTRSSRELELILNFRDDMNLNNELARLKLAIKYRQKEFVAQPNCQQLLAS
RWYDEFPGWRRRHWAGKLITCVFIGLMFPLLSLCYLVAPKSRYGLFIRKP
FIKFICHTASYLTFLFLLLLASQHIVSNNPDRQGPKPTTVEWMILPWVLG
FIWTEIKQMWDGGFQDYIHDWWNLMDFVMNSLYLATISLKIVAYVKYSGC
KPRDTWEMWHPTLVAEAVFAIANIFSSLRLISLFTANSHLGPLQISLGRM
LLDILKFLFIYCLVLLAFANGLNQLYFYYENSEGMTCKGIRCERQNNAFS
TLFETLQSLFWSIFGLISLYVTNVKADHKFTEFVGATMFGTYNVISLVVL
LNMLIAMMNNSYQHIADHADIEWKFARTKLWMSYFEEGGTLPPPFNIIPS
PKSICYLITWIKVHVFKRRSKRTETFGTLGRRAAENVRLNHQYQEVLRNL
VKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRYEVIGMM
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7b1g Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7b1g Structural basis of TRPC4 regulation by calmodulin and pharmacological agents.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		E417 Q420 D438
Binding residue
(residue number reindexed from 1)		E355 Q358 D376
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0015279 store-operated calcium channel activity
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006812 monoatomic cation transport
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034703 cation channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7b1g, PDBe:7b1g, PDBj:7b1g
PDBsum7b1g
PubMed33236980
UniProtU3N7D8

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