Structure of PDB 7b07 Chain A Binding Site BS01

Receptor Information
>7b07 Chain A (length=749) Species: 71997 (Thermococcus gorgonarius) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MILDTDYITEDGKPVIRIFKKENGEFKIDYDRNFEPYIYALLKDDSAIED
VKKITAERHGTTVRVVRAEKVKKKFLGRPIEVWKLYFTHPQDQPAIRDKI
KEHPAVVDIYEYDIPFAKRYLIDKGLIPMEGDEELKMLAFAIATLYHEGE
EFAEGPILMISYADEEGARVITWKNIDLPYVDVVSTEKEMIKRFLKVVKE
KDPDVLITYNGDNFDFAYLKKRSEKLGVKFILGREGSEPKIQRMGDRFAV
EVKGRIHFDLYPVIRRTINLPTYTLEAVYEAIFGQPKEKVYAEEIAQAWE
TGEGLERVARYSMEDAKVTYELGKEFFPMEAQLSRLVGQSLWDVSRSSTG
NLVEWFLLRKAYERNELAPNKPDERELARRRESYAGGYVKEPERGLWENI
VYLDFRSLYPSIIITHNVSPDTLNREGCEEYDVAPQVGHKFCKDFPGFIP
SLLGDLLEERQKVKKKMKATIDPIEKKLLDYRQRLIKILANSFYGYYGYA
KARWYCKECAESVTAWGRQYIETTIREIEEKFGFKVLYADTDGFFATIPG
ADAETVKKKAKEFLDYINAKLPGLLELEYEGFYKRGFFATKKKYAVIDEE
DKITTRGLKMVRRDWSEIAKETQARVLEAILKHGDVEEAVRIVKEVTEKL
SKYEVPPEQLVIYQPITKQLHDYRARGPHVSVAKRLAARGIVISYIVPKG
SGRIGDRAIPFDEFDPAKHKYDAGYYIENQVLPAVERILRAFGYRKEDL
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7b07 Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7b07 Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution.
Resolution3.099 Å
Binding residue
(original residue number in PDB)		D4 T5
Binding residue
(residue number reindexed from 1)		D4 T5
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004527 exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0071897 DNA biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7b07, PDBe:7b07, PDBj:7b07
PDBsum7b07
PubMed33302546
UniProtP56689|DPOL_THEGO DNA polymerase (Gene Name=pol)

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