Structure of PDB 7awm Chain A Binding Site BS01

Receptor Information
>7awm Chain A (length=412) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKKKVQNITKEDVKSFLRRNALLLLTVLAVILGVVLGFLLRPYPLSPREV
KYFAFPGELLMRMLKMLILPLIVSSLITGLASLDAKASGRLGMRAVVYYM
STTIIAVVLGIILVLIIHPEVLDCFLDLARNIFPSNLVSAAFRSYSTQEV
EGMNILGLVVFSMVFGFALGKMGEQGQLLVDFFNSLNEATMKLVAIIMWY
APLGILFLIAGKIVGGQLGMYMVTVIVGLVIHGLIVLPLIYFLITRKNPF
VFIAGILQALITALGTSSSSATLPITFKCLEENNGVDKRITRFVLPVGAT
INMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGIPQA
GLVTMVIVLTAVGLPTDDITLIIAVDWLLDRFRTMVNVLGDALGAGIVEH
LSRKELEKQDAE
Ligand information
Ligand IDASP
InChIInChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1
InChIKeyCKLJMWTZIZZHCS-REOHCLBHSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C(C(C(=O)O)N)C(=O)O
OpenEye OEToolkits 1.7.0C([C@@H](C(=O)O)N)C(=O)O
CACTVS 3.370N[CH](CC(O)=O)C(O)=O
CACTVS 3.370N[C@@H](CC(O)=O)C(O)=O
ACDLabs 12.01O=C(O)CC(N)C(=O)O
FormulaC4 H7 N O4
NameASPARTIC ACID
ChEMBLCHEMBL274323
DrugBankDB00128
ZINCZINC000000895032
PDB chain7awm Chain A Residue 604 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7awm The ion-coupling mechanism of human excitatory amino acid transporters.
Resolution3.25 Å
Binding residue
(original residue number in PDB)		S344 S345 T382 G422 I423 A426 G427 D456 R459 T460
Binding residue
(residue number reindexed from 1)		S268 S269 T306 G346 I347 A350 G351 D380 R383 T384
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015293 symporter activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:7awm, PDBe:7awm, PDBj:7awm
PDBsum7awm
PubMed34747040
UniProtP43003;
Q15758|AAAT_HUMAN Neutral amino acid transporter B(0) (Gene Name=SLC1A5)

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