Structure of PDB 7ap8 Chain A Binding Site BS01

Receptor Information
>7ap8 Chain A (length=1268) Species: 502057 (Vaccinia virus GLV-1h68) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVISKVTYSLYDQKEINATDIIISHVKNDDDIGTVKDGRLGAMDGALCKT
CGKTELECFGHWGKVSIYKTHIVKPEFISEIIRLLNHICIHCGLLRSREP
YSDDINLKELSGHALRRLKDKILSKKKSCWNSECMQPYQKITFSKKKVCF
VNKLDDINVPNSLIYQKLISIHEKFWPLLEIHQYPANLFYTDYFPIPPLI
IRPAISFWIDSIPKETNELTYLLGMIVKNCNLNADEQVIQKAVIEYDDIK
IISNNTTSINLSYITSGKNNMIRSYIVARRKDQTARSVIGPSTSITVNEV
GMPAYIRNTLTEKIFVNAFTVDKVKQLLASNQVKFYFNKRLNQLTRIRQG
KFIKNKIHLLPGDWVEVAVQEYTSIIFGRQPSLHRYNVIASSIRATEGDT
IKISPGIANSQNADFDGDEEWMILEQNPKAVIEQSILMYPTTLLKHDIHG
APVYGSIQDEIVAAYSLFRIQDLCLDEVLNILGKYGREFDPKGKCKFSGK
DIYTYLIGEKINYPGLLKDGEIIANDVDSNFVVAMRHLSLAGLLSDHKSN
VEGINFIIKSSYVFKRYLSIYGFGVTFKDLRPNSTFTNKLEAINVEKIEL
IKEAYAKYLNDVRDGKIVPLSKALEADYVESMLSNLTNLNIREIEEHMRQ
TLIDDPDNNLLKMAKAGYKVNPTELMYILGTYGQQRIDGEPAETRVLGRV
LPYYLPDSKDPEGRGYILNSLTKGLTGSQYYFSMLVARSQSTDIVCETSR
TGTLARKIIKKMEDMVVDGYGQVVIGNTLIKYAANYTKILGSVCKPVDLI
YPDESMTWYLEISALWNKIKQGFVYSQKQKLAKKTLAPFNFLVFVKPTTE
DNAIKVKDLYDMIHNVIDDVREKYFFTVSNIDFMEYIFLTHLNPSRIRIT
KETAITIFEKFYEKLNYTLGGGTPIGIISAQVLSEKFTQQALSSFHTTEK
SGAVKQKLGFNEFNNLTNLSKNKTEIITLVSDDISKLQSVKINFEFVCLG
ELNPNITLRKETDKYVVDIIVNRLYIKRAEITELVVEYMIERFISFSVIV
KEWGMETFIEDEDNIRFTVYLNFVEPEELNLSKFMMVLPGAANKGKISKF
KIPISDYTGYDDFNQTKKLNKMTVELMNLKELGSFDLENVNVYPGVWNTY
DIFGIEAAREYLCEAMLNTYGEGFDYLYQPCDLLASLLCASYEPESVNKF
KFGAASTLKRATFGDNKALLNAALHKKSEPINDNSSCHFFSKVPNIGTGY
YKYFIDLGLLMRMERKLS
Ligand information
Receptor-Ligand Complex Structure
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PDB7ap8 Structural basis of the complete poxvirus transcription initiation process.
Resolution3.15 Å
Binding residue
(original residue number in PDB)		R281 R287
Binding residue
(residue number reindexed from 1)		R280 R286
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ap8, PDBe:7ap8, PDBj:7ap8
PDBsum7ap8
PubMed34556871
UniProtQ1PIV1

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