Structure of PDB 7alt Chain A Binding Site BS01

Receptor Information
>7alt Chain A (length=270) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AGNFELEILEISNTNSHLLNGYCCGMPAELRATKTIGCSPCTTAFRLCLK
EYQTTEQGASISTGCSFGNATTKILGGSSFVLSDPGVGAIVLPFTFRWTK
SFTLILQALDMYNTSYPDAERLIEETSYSGVILPSPEWKTLDHIGRNARI
TYRVRVQCAVTYYNTTCTTFCRPRDDQFGHYACGSEGQKLCLNGWQGVNC
EEAICKAGCDPVHGKCDRPGECECRPGWRGPLCNECMVYPGCKHGSCNGS
AWKCVCDTNWGGILCDQDLN
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7alt Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7alt The conserved C2 phospholipid-binding domain in Delta contributes to robust Notch signalling.
Resolution2.03 Å
Binding residue
(original residue number in PDB)		N92 N94 N226
Binding residue
(residue number reindexed from 1)		N13 N15 N147
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0007154 cell communication
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organism development
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:7alt, PDBe:7alt, PDBj:7alt
PDBsum7alt
PubMed34347930
UniProtP18168|SERR_DROME Protein serrate (Gene Name=Ser)

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