Structure of PDB 7age Chain A Binding Site BS01

Receptor Information
>7age Chain A (length=339) Species: 5480 (Candida parapsilosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DSISLSLINEGPSYASKVSVGSNKQQQTVIIDTGSSDFWVVDSNAQCGKG
VDCKSSGTFTPSSSSSYKNLGAAFTIRYGDGSTSQGTWGKDTVTINGVSI
TGQQIADVTQTSVDQGILGIGYTSNEAVYDTSGRQTTPNYDNVPVTLKKQ
GKIRTNAYSLYLNSPSAETGTIIFGGVDNAKYSGKLVAEQVTSSQALTIS
LASVNLKGSSFSFGDGALLDSGTTLTYFPSDFAAQLADKAGARLVQVARD
QYLYFIDCNTDTSGTTVFNFGNGAKITVPNTEYVYQNGDGTCLWGIQPSD
DTILGDNFLRHAYLLYNLDANTISIAQVKYTTDSSISAV
Ligand information
Receptor-Ligand Complex Structure
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PDB7age Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis .
Resolution1.3 Å
Binding residue
(original residue number in PDB)		I30 D32 G34 Y78 G79 D80 I117 D220 G222 T223 T224 Y227 Y285 I303
Binding residue
(residue number reindexed from 1)		I30 D32 G34 Y78 G79 D80 I117 D220 G222 T223 T224 Y227 Y285 I303
Enzymatic activity
Catalytic site (original residue number in PDB) D32 S35 D37 W39 Y78 D220 T223
Catalytic site (residue number reindexed from 1) D32 S35 D37 W39 Y78 D220 T223
Enzyme Commision number 3.4.23.24: candidapepsin.
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region

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Biological Process
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Cellular Component
External links
PDB RCSB:7age, PDBe:7age, PDBj:7age
PDBsum7age
PubMed33843395
UniProtP32951|CARP1_CANPA Candidapepsin-1 (Gene Name=SAPP1)

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