Structure of PDB 7afu Chain A Binding Site BS01

Receptor Information
>7afu Chain A (length=357) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFEGQMAEYPTISIDRFDRENLRARAYFLSACHKDHMKGLRAPTLKRRLE
CSLKVYLYCSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDEASGE
KEEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAQGEAARMELLHS
GGRVKDIQSVYLDTTFCDPRFYQIPSREECLSGVLELVRSWITRSPYHVV
WLNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPEILHHLTTDRNTQ
IHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPSTMWFGERSRKTN
VIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPTTMDKVVEI
LKPLCRS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7afu Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7afu Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.
Resolution1.56 Å
Binding residue
(original residue number in PDB)		H228 H254 C256 C272
Binding residue
(residue number reindexed from 1)		H226 H252 C254 C270
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
External links
PDB RCSB:7afu, PDBe:7afu, PDBj:7afu
PDBsum7afu
PubMed34387696
UniProtQ96SD1|DCR1C_HUMAN Protein artemis (Gene Name=DCLRE1C)

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