Structure of PDB 7adv Chain A Binding Site BS01

Receptor Information
>7adv Chain A (length=367) Species: 11963 (Human spumaretrovirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DAELDQLLQGHYIKGYPKQYTYFLEDGKVKVSRPEGVKIIPPQSDRQKIV
LQAHNLAHTGREATLLKIANLYWWPNMRKDVVKQLGRCQQCLITNASNKA
SGPILRPDRPQKPFDKFFIDYIGPLPPSQGYLYVLVVVDGMTGFTWLYPT
KAPSTSATVKSLNVLTSIAIPKVIHSDQGAAFTSSTFAEWAKERGIHLEF
STPYHPQSSGKVERKNSDIKRLLTKLLVGRPTKWYDLLPVVQLALNNTYS
PVLKYTPHQLLFGIDSNTPFANQDTLDLTREEELSLLQEIRTSLYHPSTP
PASSRSWSPVVGQLVQERVARPASLRPRWHKPSTVLKVLNPRTVVILDHL
GNNRTVSIDNLKPTSHQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7adv HIV-1 Integrase Inhibitors with Modifications That Affect Their Potencies against Drug Resistant Integrase Mutants.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		I112 L113 R114 P115 E207 S209 T210 Q215 S216 G218 K219 R222 R229 S258 P259 N348 R350 T351
Binding residue
(residue number reindexed from 1)		I104 L105 R106 P107 E199 S201 T202 Q207 S208 G210 K211 R214 R221 S250 P251 N340 R342 T343
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:7adv, PDBe:7adv, PDBj:7adv
PDBsum7adv
PubMed33686850
UniProtP14350|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)

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