Structure of PDB 7a8u Chain A Binding Site BS01

Receptor Information

>7a8u Chain A (length=474) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLED
FRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIA
GAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQ
ILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELD
YHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFA
KRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGER
QSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRD
QSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALE
DQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRV
GWELLLTTIARTINEVETQILTRD

Ligand information

>7a8u Chain B (length=11) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

YKSFNRTAMPY

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7a8u Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with alpha-actinin.
Resolution	3.802 Å
Binding residue (original residue number in PDB)	R398 K405 D456 R457 Q460 A463 E467
Binding residue (residue number reindexed from 1)	R126 K133 D184 R185 Q188 A191 E195

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:7a8u, PDBe:7a8u, PDBj:7a8u
PDBsum	7a8u
PubMed	34049882
UniProt	P35609\|ACTN2_HUMAN Alpha-actinin-2 (Gene Name=ACTN2)

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