Structure of PDB 7a8r Chain A Binding Site BS01

Receptor Information

>7a8r Chain A (length=531) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MSSPASWNKEDFPWSGKVKDVLQNVFKLQKFRPLQLETINVTMSGKEVFL
VMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISATML
NASSPKEHVKWVHAEMVNKNSKLKLIYVTPEKIAKSKMFMSRLEKAYEAR
RFTRIAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLIGLTATATSHV
LKDAQKILCVEKCFTFTASFNRPNLYYEVRQKPSNTEDFIEDIVKLINGR
YKGQSGIIYCFSQKDSEQVTISLQKLGIPAGAYHANMEPEDKTKVHRRWA
ANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRDDMK
ADCILYYGFGDIFRISSMVVMENVGQQKLYEMVSYCQNINKCRRVLIAQH
FDEVWSPEACNKMCDNCCKEISFERKNVTAYCRDLIKILKQAEDLNEKLT
PLKLIDSWMGKGASKLRVAGLAPPTLPREDLEKIIAHFLIQQYLKEDYSF
TAYATISYLKVGPKANLLNNEAHVITMRVKK

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

7a8r Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7a8r Endogenous Bos taurus RECQL is predominantly monomeric and more active than oligomers.
Resolution	2.31 Å
Binding residue (original residue number in PDB)	C453 C471 C475 C478
Binding residue (residue number reindexed from 1)	C392 C410 C414 C417
Annotation score	1

Enzymatic activity

Enzyme Commision number

5.6.2.4: DNA 3'-5' helicase.

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0004386	helicase activity
GO:0005524	ATP binding

	Biological Process
GO:0006310	DNA recombination

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Molecular Function

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Biological Process

External links

PDB	RCSB:7a8r, PDBe:7a8r, PDBj:7a8r
PDBsum	7a8r
PubMed	34496242
UniProt	A0JN36

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