Structure of PDB 7a2w Chain A Binding Site BS01

Receptor Information

>7a2w Chain A (length=61) Species: 9606 (Homo sapiens)

GGVTLFVALYDYEARTEDDLSFHKGEKFQIVNNTEGDWWLAHSLTTGETG
YIPSNYVAPVD

Ligand information

>7a2w Chain B (length=12) Species: 32630 (synthetic construct)

VSLARRPLPPLP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7a2w Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex with VSL12 at pH 3.0
• Resolution: 0.99 Å
• Binding residue (original residue number in PDB): Y91 D99 D100 E116 G117 D118 W119 Y132 P134 N136 Y137
• Binding residue (residue number reindexed from 1): Y10 D18 D19 E35 G36 D37 W38 Y51 P53 N55 Y56

Enzymatic activity

• Enzyme Commision number: 2.7.10.2: non-specific protein-tyrosine kinase.

External links

• PDB: RCSB:7a2w, PDBe:7a2w, PDBj:7a2w
• PDBsum: 7a2w
• UniProt: P06241|FYN_HUMAN Tyrosine-protein kinase Fyn (Gene Name=FYN)