Structure of PDB 7a2g Chain A Binding Site BS01

Receptor Information
>7a2g Chain A (length=420) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKAMLNLLFSPRATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPH
LEYFVRLEVRRGDLAALLSGVRQVSEDVRSPAGPKVPWFPRKVSELDKCH
HLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAE
EIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSR
FLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPD
CCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFG
LCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTY
QSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDSPQAVRR
SLEGVQDELDTLAHALSAIG
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain7a2g Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7a2g Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		H330 H335 E375
Binding residue
(residue number reindexed from 1)		H253 H258 E298
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.16.2: tyrosine 3-monooxygenase.
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0004511 tyrosine 3-monooxygenase activity
GO:0005506 iron ion binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Biological Process
GO:0009072 aromatic amino acid metabolic process
GO:0042423 catecholamine biosynthetic process

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:7a2g, PDBe:7a2g, PDBj:7a2g
PDBsum7a2g
PubMed35013193
UniProtP07101|TY3H_HUMAN Tyrosine 3-monooxygenase (Gene Name=TH)

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