Structure of PDB 7a24 Chain A Binding Site BS01

Receptor Information
>7a24 Chain A (length=429) Species: 3712 (Brassica oleracea) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
THFGGLKDEDRIFTNLYGLHDPFLKGAMKRGDWHRTKDLVLKGTDWIVNE
MKKSGLRGRGGAGFPSGLKWSFMPKVSDGRPSYLVVNADESEPGTCKDRE
IMRHDPHKLLEGCLIAGVGMRASAAYIYIRGEYVNERLNLEKARREAYAA
GLLGKNACGSGYDFEVYIHFGAGAYICGEETALLESLEGKQGKPRLKPPF
PANAGLYGCPTTVTNVETVAVSPTILRRGPEWFSSFGRKNNAGTKLFCIS
GHVNKPCTVEEEMSIPLKELIERHCGGVRGGWDNLLAIIPGGSSVPLIPK
NICEDVLMDFDALKAVQSGLGTAAVIVMDKSTDVVDAIARLSYFYKHESC
GQCTPCREGTGWLWMIMERMKVGNAKLEEIDMLQEVTKQIEGHTICALGD
AAAWPVQGLIRHFRPELERRIRERAEREL
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain7a24 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7a24 Specific features and assembly of the plant mitochondrial complex I revealed by cryo-EM.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		P246 C402 G403 Q404 C405 C408 I447 C448 L450
Binding residue
(residue number reindexed from 1)		P194 C350 G351 Q352 C353 C356 I395 C396 L398
Annotation score1
Enzymatic activity
Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).
Gene Ontology
Molecular Function
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0051287 NAD binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005886 plasma membrane
GO:0045271 respiratory chain complex I

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7a24, PDBe:7a24, PDBj:7a24
PDBsum7a24
PubMed33060577
UniProtQ9FNN5|NDUV1_ARATH NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (Gene Name=At5g08530)

[Back to BioLiP]