Structure of PDB 7a0v Chain A Binding Site BS01

Receptor Information
>7a0v Chain A (length=333) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKPKKIRVCVGTWNVNGGKQFRSINQTLTDWLLDAPKLAGIQEFQDKRSK
PTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLAS
EQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHT
TSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLFSHDYVFWCGD
FNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTF
APTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNYT
WTPGTLLHYGRAELKTSDHRPVVALIDIDIFEV
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7a0v Chain A Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7a0v A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		N543 E591
Binding residue
(residue number reindexed from 1)		N16 E61
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.36: phosphoinositide 5-phosphatase.
Gene Ontology
Molecular Function
GO:0016791 phosphatase activity
Biological Process
GO:0046856 phosphatidylinositol dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7a0v, PDBe:7a0v, PDBj:7a0v
PDBsum7a0v
PubMed33349335
UniProtO43426|SYNJ1_HUMAN Synaptojanin-1 (Gene Name=SYNJ1)

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