Structure of PDB 6zy8 Chain A Binding Site BS01

Receptor Information
>6zy8 Chain A (length=1159) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFV
PGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVV
EHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFT
VETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKM
QSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDK
LDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDY
VADQIVTKLVDVVKKKNVKAHQVKNHMWIFVNALIENPTFDSQTKENMTL
QPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLNKKCSAVKHN
RIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGV
FPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRY
GKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKN
KQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKR
HRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPED
YLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTC
FKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNL
LQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDN
QRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGE
EPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQ
TYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERV
GLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLR
KEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYD
SDPVKAWKEAQQKVSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELD
TLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQ
MAEVLPSPR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6zy8 Structural basis for allosteric regulation of Human Topoisomerase II alpha.
Resolution7.4 Å
Binding residue
(original residue number in PDB)		L491 I856 G857 S861 S994
Binding residue
(residue number reindexed from 1)		L458 I823 G824 S828 S961
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0003916 DNA topoisomerase activity
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0008301 DNA binding, bending
GO:0042803 protein homodimerization activity
GO:0043130 ubiquitin binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000712 resolution of meiotic recombination intermediates
GO:0000819 sister chromatid segregation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
GO:0006266 DNA ligation
GO:0006974 DNA damage response
GO:0007059 chromosome segregation
GO:0007143 female meiotic nuclear division
GO:0030261 chromosome condensation
GO:0030263 apoptotic chromosome condensation
GO:0040016 embryonic cleavage
GO:0042752 regulation of circadian rhythm
GO:0043065 positive regulation of apoptotic process
GO:0045870 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048511 rhythmic process
GO:0060255 regulation of macromolecule metabolic process
GO:1905463 negative regulation of DNA duplex unwinding
Cellular Component
GO:0000228 nuclear chromosome
GO:0000775 chromosome, centromeric region
GO:0000793 condensed chromosome
GO:0001673 male germ cell nucleus
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005814 centriole
GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
GO:0032991 protein-containing complex
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6zy8, PDBe:6zy8, PDBj:6zy8
PDBsum6zy8
PubMed34016969
UniProtP11388|TOP2A_HUMAN DNA topoisomerase 2-alpha (Gene Name=TOP2A)

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