Structure of PDB 6zww Chain A Binding Site BS01

Receptor Information

>6zww Chain A (length=744) Species: 562 (Escherichia coli)

TEQQKLTFTALQQRLDSLMLRDRLRFSRRLHGVKKVKNPDAQQAIFQEMA
KEIDQAAGKVLLREAARPEITYPDNLPVSQKKQDILEAIRDHQVVIVAGE
TGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPG
GCIGYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHE
RSLNIDFLLGYLKELLPRRPDLKIIITSATIDPERFSRHFNNAPIIEVSG
RTYPVEVRYRPIRDQLQAIFDAVDELSQESHGDILIFMSGEREIRDTADA
LNKLNLRHTEILPLYARLSNSEQNRVFQSHSGRRIVLATNVAETSLTVPG
IKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICI
RLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDK
RNIQDGVRLLEELGAITTDEQASAYKLTPLGRQLSQLPVDPRLARMVLEA
QKHGCVREAMIITSALSIQDPRERPMDKQQASDEKHRRFHDKESDFLAFV
NLWNYLGEQQKALSSNAFRRLCRTDYLNYLRVREWQDIYTQLRQVVKELG
IPVNSEPAEYREIHIALLTGLLSHIGMKDADKQEYTGARNARFSIFPGSG
LFKKPPKWVMVAELVETSRLWGRIAARIDPEWVEPVAQHLIKRTYSEPHW
ERAQGAVMATEKVTVYGLPIVAARKVNYSQIDPALCRELFIRHA

Ligand information

>6zww Chain B (length=12)

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............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zww Large-scale ratcheting in a bacterial DEAH/RHA-type RNA helicase that modulates antibiotics susceptibility.
• Resolution: 3.16 Å
• Binding residue (original residue number in PDB): P130 R132 R159 T174 G176 I177 A180 G299 E300 A325 N349 V350 S354 R370 L383 Q495 P497 R533 Q600 F655 P656 F661 V674 T676 W680 R682
• Binding residue (residue number reindexed from 1): P129 R131 R158 T173 G175 I176 A179 G290 E291 A316 N340 V341 S345 R361 L374 Q486 P488 R524 Q591 F646 P647 F652 V665 T667 W671 R673

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003724 RNA helicase activity
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity

External links

• PDB: RCSB:6zww, PDBe:6zww, PDBj:6zww
• PDBsum: 6zww
• PubMed: 34290142
• UniProt: P43329|HRPA_ECOLI ATP-dependent RNA helicase HrpA (Gene Name=hrpA)