Structure of PDB 6zkz Chain A Binding Site BS01

Receptor Information
>6zkz Chain A (length=272) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDNDAASPRMVPRAPW
MEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMHGC
ELGPDGRFLRGYEQCAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDAS
EAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATL
RCWALGFYPAEITLTWQQDGEQDTELVETRPAGDGTFQKWAAVVVPSGEE
QRYTCHVQHEGLPEPVTLRWKP
Ligand information
>6zkz Chain C (length=9) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
RLPAKAPLK
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6zkz Structure-guided stabilization of pathogen-derived peptide-HLA-E complexes using non-natural amino acids conserves native TCR recognition.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		Y7 H9 M45 E63 A67 N77 Y84 W97 H99 C116 S143 K146 H155 Q156 Y159 W167 Y171
Binding residue
(residue number reindexed from 1)		Y6 H8 M44 E62 A66 N76 Y83 W96 H98 C115 S142 K145 H154 Q155 Y158 W166 Y170
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:6zkz, PDBe:6zkz, PDBj:6zkz
PDBsum6zkz
PubMed35108401
UniProtP13747|HLAE_HUMAN HLA class I histocompatibility antigen, alpha chain E (Gene Name=HLA-E)

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