Structure of PDB 6zgr Chain A Binding Site BS01

Receptor Information
>6zgr Chain A (length=399) Species: 335543 (Syntrophobacter fumaroxidans MPOB) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TMPRWVPLLLGLLGSTTCGMLLYAWSVFIKPLNAEFSRAEIAMAFAICCL
IFGLMTFPAGRLSDKMGPRKVVMTGGVLLAIGFILSGFIQSKYQLYITYG
VIAGFGGGMIYLPPIATAPKWWPDRRALATGFAVVGLGLGSFLMGPLATY
IIEWRYVFWYCGVAMGIMALIAGAFLEPPPAGWKPAGYTAAPKVTRDWTY
EEAKGDTKFWLLYLAYFCGSFAGLMVIGHLAGFGRDAGLTAMAAAGAVSS
LAFSNAATRILSGWFVDKIGIRVYFAALFALQTAAMIAIFQLGGSVVGLS
IVAIVIGWNYGAMFTLFPATCLQFYGPTAQGSNYGLLFTACGLAGFAGPW
VGGWLKDTTGTYYLPFLCAAALCALGTAIVFMTKPPEKKHALELEVLFQ
Ligand information
Ligand ID1HN
InChIInChI=1S/C11H8O3/c12-10-8-4-2-1-3-7(8)5-6-9(10)11(13)14/h1-6,12H,(H,13,14)
InChIKeySJJCQDRGABAVBB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0c1ccc2c(c1)ccc(c2O)C(=O)O
ACDLabs 12.01O=C(O)c2ccc1ccccc1c2O
CACTVS 3.370OC(=O)c1ccc2ccccc2c1O
FormulaC11 H8 O3
Name1-hydroxynaphthalene-2-carboxylic acid
ChEMBLCHEMBL229299
DrugBank
ZINCZINC000000037856
PDB chain6zgr Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6zgr The making of a potent L-lactate transport inhibitor
Resolution2.46 Å
Binding residue
(original residue number in PDB)		F60 Y119 L145 R280 Y331 F335 F359
Binding residue
(residue number reindexed from 1)		F52 Y111 L137 R259 Y310 F314 F338
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015293 symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6zgr, PDBe:6zgr, PDBj:6zgr
PDBsum6zgr
PubMed
UniProtA0LNN5|SFMCT_SYNFM L-lactate transporter (Gene Name=Sfum_3364)

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