Structure of PDB 6yzh Chain A Binding Site BS01

Receptor Information

>6yzh Chain A (length=344) Species: 9606 (Homo sapiens)

GGRLVPRFGEGEGSEGPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQD
DYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILEN
LRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYM
YEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQE
YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHD
NYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHS
ENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKEN

Ligand information

>6yzh Chain D (length=9) Species: 9606 (Homo sapiens)

AARLYGFKA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6yzh Development of small cyclic peptides targeting the CK2 alpha / beta interface.
• Resolution: 1.19 Å
• Binding residue (original residue number in PDB): Q36 Y39 Q40 L41 V42 E52 F54 V67 I69 D103 A110
• Binding residue (residue number reindexed from 1): Q49 Y52 Q53 L54 V55 E65 F67 V80 I82 D116 A123

Enzymatic activity

• Catalytic site (original residue number in PDB): D156 K158 N161 D175 S194
• Catalytic site (residue number reindexed from 1): D169 K171 N174 D188 S207
• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004674 protein serine/threonine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:6yzh, PDBe:6yzh, PDBj:6yzh
• PDBsum: 6yzh
• PubMed: 35343996
• UniProt: P68400|CSK21_HUMAN Casein kinase II subunit alpha (Gene Name=CSNK2A1)