Structure of PDB 6yw2 Chain A Binding Site BS01

Receptor Information
>6yw2 Chain A (length=209) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGK
FTDGIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRT
KAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIF
PEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADER
ARAKVKYLT
Ligand information
Receptor-Ligand Complex Structure
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PDB6yw2 Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.
Resolution2.14 Å
Binding residue
(original residue number in PDB)		K186 P187 L188 Y197 P200 C201 K204 H205 V209 V210 D211 D212 F213
Binding residue
(residue number reindexed from 1)		K2 P3 L4 Y13 P16 C17 K20 H21 V25 V26 D27 D28 F29
Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:6yw2, PDBe:6yw2, PDBj:6yw2
PDBsum6yw2
PubMed33319810
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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