Structure of PDB 6yu7 Chain A Binding Site BS01

Receptor Information
>6yu7 Chain A (length=442) Species: 86665 (Halalkalibacterium halodurans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GREQWASRLGFILAAMGSAVGLGNIWRFSYVTGENGGAAFLLVYLGFIAL
IGIPIVLAEFTIGRRAQSDAVGSFEKLAPGKPWKVAGLMGVAAGFLILSF
YGVIAGWILFYLFNYITGQLWSAPAEGFGGFFEGFIANPTLPLFWQALFM
IATIWIVAIGVKKGIERSNKILMPLLGVLLIALAIYSLTLGGAKEGLAFL
FSPDWSALKDPGVYLAAISQAFFTLSLGMGALITYGSYVSKDSRLPGAAV
SVAGLDTAFAIIAGIMIFPAVFALGLSPSGGPGLVFVVLPDIFDSIRLGP
IVGIAFFILLGAAALSSAVSLLEVPVAYFMRKFDWSRKQAAITLGVIITL
LGIPSSLSFGVLGEVTIIPGLNIFDSVDFIASSVFLPLGGMIIALFIGWG
WKTSDALAESDLTDSVWGKLWILSLRFIAPIAILIVFLSAFQ
Ligand information
Ligand IDTYR
InChIInChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1
InChIKeyOUYCCCASQSFEME-QMMMGPOBSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(N)Cc1ccc(O)cc1
OpenEye OEToolkits 1.5.0c1cc(ccc1C[C@@H](C(=O)O)N)O
OpenEye OEToolkits 1.5.0c1cc(ccc1CC(C(=O)O)N)O
CACTVS 3.341N[CH](Cc1ccc(O)cc1)C(O)=O
CACTVS 3.341N[C@@H](Cc1ccc(O)cc1)C(O)=O
FormulaC9 H11 N O3
NameTYROSINE
ChEMBLCHEMBL925
DrugBankDB00135
ZINCZINC000000266964
PDB chain6yu7 Chain A Residue 506 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6yu7 A non-helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		S25 A26 G28 G30 Y108 F230 T231 S233 M236 L328
Binding residue
(residue number reindexed from 1)		S18 A19 G21 G23 Y101 F223 T224 S226 M229 L321
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:6yu7, PDBe:6yu7, PDBj:6yu7
PDBsum6yu7
PubMed33155685
UniProtQ9KDT3

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