Structure of PDB 6yi1 Chain A Binding Site BS01

Receptor Information

>6yi1 Chain A (length=329) Species: 9606 (Homo sapiens)

GPAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSP
GSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAK
RHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLK
TVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGA
RGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELG
LLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTM
DDNEENLDESTIDNLNKILQVFVLEYLHL

Ligand information

>6yi1 Chain C (length=3) Species: 32630 (synthetic construct)

cFA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6yi1 Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer's Disease.
• Resolution: 1.92 Å
• Binding residue (original residue number in PDB): D159 E201 E202 W207 D248 I303 Q304 W329 H330
• Binding residue (residue number reindexed from 1): D127 E169 E170 W175 D216 I271 Q272 W297 H298

Enzymatic activity

• Enzyme Commision number: 2.3.2.5: glutaminyl-peptide cyclotransferase.

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008270 zinc ion binding
• GO:0016603 glutaminyl-peptide cyclotransferase activity
• GO:0016746 acyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
• GO:0036211 protein modification process

Cellular Component

• GO:0005576 extracellular region
• GO:0035580 specific granule lumen
• GO:0070062 extracellular exosome
• GO:1904724 tertiary granule lumen
• GO:1904813 ficolin-1-rich granule lumen

External links

• PDB: RCSB:6yi1, PDBe:6yi1, PDBj:6yi1
• PDBsum: 6yi1
• PubMed: 32551535
• UniProt: Q16769|QPCT_HUMAN Glutaminyl-peptide cyclotransferase (Gene Name=QPCT)