Structure of PDB 6ya7 Chain A Binding Site BS01

Receptor Information
>6ya7 Chain A (length=350) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIA
LKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLE
HESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRR
LKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERPASLTCDCYATDKVCS
ICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGR
YPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKL
CERLRGAGAGGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMS
Ligand information
Receptor-Ligand Complex Structure
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PDB6ya7 Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase.
Resolution1.67 Å
Binding residue
(original residue number in PDB)		T68 F69 S96 R100 D177 K179 N182 D196 G198 L199 Q201 V214 R373 A374 G375 T376 R380 Y412
Binding residue
(residue number reindexed from 1)		T30 F31 S58 R62 D139 K141 N144 D158 G160 L161 Q163 V176 R212 A213 G214 T215 R219 Y251
Enzymatic activity
Catalytic site (original residue number in PDB) D177 K179 N182 D196 T376
Catalytic site (residue number reindexed from 1) D139 K141 N144 D158 T215
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6ya7, PDBe:6ya7, PDBj:6ya7
PDBsum6ya7
PubMed32521228
UniProtO00311|CDC7_HUMAN Cell division cycle 7-related protein kinase (Gene Name=CDC7)

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