Structure of PDB 6y0c Chain A Binding Site BS01

Receptor Information
>6y0c Chain A (length=688) Species: 100673 (Influenza C virus (C/Johannesburg/1/66)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKTFAEIAEAFLEPEAVRIAKEAVEEYGDHERKIIQIGIHFQVCCMFCDE
YLSTNGSDRFVLIEGRKRGTAVSLQNELCKSYDLEPLPFLCDIFDREEKQ
FVEIGITRKADDSYFQSKFGKLGNSCKIFVFSYDGRLDKNCEGPMEEQKL
RIFSFLATAADFLRKENMFNEIFLPDNEETIIEMKKGKTFLELRDESVPL
PFQTYEQMKDYCEKFKGNPRELASKVSQMQSNIKLPIKHYEQNKFRQIRL
PKGPMAPYTHKFLMEEAWMFTKISDPERSRAGEILIDFFKKGNLSAIRPK
DKPLQGKYPIHYKNLWNQIKAAIADRTMVINENDHSEFLGGIGRASKKIP
EISLTQDVITTEGLKQSENKLPEPRSFPRWFNAEWMWAIKDSDLTGWVPM
AEYPPADNELEDYAEHLNKTMEGVLQGTNCAREMGKCILTVGALMTECRL
FPGKIKVVPIYARSKERKPSEMDCLFGICVKSKSHLNKDDGMYTIITFEF
SIREPNLEKHQKYTVFEAGHTTVREVPLYLYCRTTALSKIKNDWLSKARR
CFITTMDTVETICLRESAKAEENLVEKTLNEKQMWIGKKNGELIAQPLRE
ALRVQLVQQFYFCIYNDSQLEGFCNEQKKILMALEGDKKNKSSFGFNPEG
LLEKIEECLINNPMCLFMAQRLNELVIEASKRGAKFFK
Ligand information
>6y0c Chain IN1 (length=20) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aguagaaacaagggccuuuu
.<<....>>.<<<.>>>...
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6y0c Host ANP32A mediates the assembly of the influenza virus replicase.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		S280 R281 M329 G342 I343 R345 P373 E448 L451 H494 M501 S637
Binding residue
(residue number reindexed from 1)		S279 R280 M328 G341 I342 R344 P372 E447 L450 H485 M492 S618
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075523 viral translational frameshifting
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6y0c, PDBe:6y0c, PDBj:6y0c
PDBsum6y0c
PubMed33208942
UniProtQ9IMP5|PA_INCJH Polymerase acidic protein (Gene Name=PA)

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