Structure of PDB 6xvt Chain A Binding Site BS01
Receptor Information
>6xvt Chain A (length=112) Species:
9606
(Homo sapiens) [
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SMSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRVV
GRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDANV
FASAMMHALEVL
Ligand information
>6xvt Chain G (length=4) Species:
32630
(synthetic construct) [
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PPPP
Receptor-Ligand Complex Structure
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PDB
6xvt
Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Resolution
1.4 Å
Binding residue
(original residue number in PDB)
Y16 W23 K69 F77 Q79 R81
Binding residue
(residue number reindexed from 1)
Y17 W24 K70 F78 Q80 R82
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6xvt
,
PDBe:6xvt
,
PDBj:6xvt
PDBsum
6xvt
PubMed
33184177
UniProt
Q8N8S7
|ENAH_HUMAN Protein enabled homolog (Gene Name=ENAH)
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