Structure of PDB 6xu2 Chain A Binding Site BS01

Receptor Information
>6xu2 Chain A (length=1091) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAAAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGQSKITFLLQAIRNT
TAAEEARQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMETQ
SSMRKKVCDIAAELARNLIDEDGNNQWPEGLKFLFDSVSSQNVGLREAAL
HIFWNFPGIFGNQQQHYLDVIKRMLVQCMQDQEHPSIRTLSARATAAFIL
ANEHNVALFKHFADLLPGFLQAVNDSCYQNDDSVLKSLVEIADTVPKYLR
PHLEATLQLSLKLCGDTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIVA
QTIPQMLAMMVDLEEDEDWANADELFDSNAVAGESALDRMACGLGGKLVL
PMIKEHIMQMLQNPDWKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLL
FLQDPHPRVRYAACNAVGQMATDFAPGFQKKFHEKVIAALLQTMEDQGNQ
RVQAHAAAALINFTEDCPKSLLIPYLDNLVKHLHSIMVLKLQELIQKGTK
LVLEQVVTSIASVADTAEEKFVPYYDLFMPSLKHIVENAVQKELRLLRGK
TIECISLIGLAVGKEKFMQDASDVMQLLLKTQTDFNDMEDDDPQISYMIS
AWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDMENMSDDDG
WEFVNLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKL
MVPLLKFYFHDGVRVAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKA
IGTEPDSDVLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFK
NQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSDILHSIFSSYKEK
VLPWFEQLLPLIVNLICPHRPWPDRQWGLCIFDDVIEHCSPASFKYAEYF
LRPMLQYVCDNSPEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQ
SADSKTKENVNATENCISAVGKIMKFKPDCVNVEEVLPHWLSWLPLHEDK
EEAVQTFNYLCDLIESNHPIVLGPNNTNLPKIFSIIAEGEMHEAIKHEDP
CAKRLANVVRQVQTSGGLWTECIAQLSPEQQAAIQELLNSA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6xu2 X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking.
Resolution2.834 Å
Binding residue
(original residue number in PDB)		Y855 K859 Q900 W901 C904 Q941 Y945 N989 D1023
Binding residue
(residue number reindexed from 1)		Y831 K835 Q876 W877 C880 Q917 Y921 N965 D999
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
GO:0008139 nuclear localization sequence binding
GO:0031267 small GTPase binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0002753 cytoplasmic pattern recognition receptor signaling pathway
GO:0006606 protein import into nucleus
GO:0006607 NLS-bearing protein import into nucleus
GO:0006610 ribosomal protein import into nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0042307 positive regulation of protein import into nucleus
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
GO:0031965 nuclear membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xu2, PDBe:6xu2, PDBj:6xu2
PDBsum6xu2
PubMed32222384
UniProtO00410|IPO5_HUMAN Importin-5 (Gene Name=IPO5)

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