Structure of PDB 6xte Chain A Binding Site BS01

Receptor Information
>6xte Chain A (length=1075) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AMAAAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGQSKITFLLQAIRN
TTAAEEARQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMET
QSSMRKKVCDIAAELARNLIDEDGNNQWPEGLKFLFDSVSSQNVGLREAA
LHIFWNFPGIFGNQQQHYLDVIKRMLVQCMQDQEHPSIRTLSARATAAFI
LANEHNVALFKHFADLLPGFLQAVNDSCYQNDDSVLKSLVEIADTVPKYL
RPHLEATLQLSLKLCGDTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIV
AQTIPQMLAMMVDLEDFDSNAVAGESALDRMACGLGGKLVLPMIKEHIMQ
MLQNPDWKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRV
RYAACNAVGQMATDFAPGFQKKFHEKVIAALLQTMEDQGNQRVQAHAAAA
LINFTEDCPKSLLIPYLDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTS
IASVADTAEEKFVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIG
LAVGKEKFMQDASDVMQLLLKTQTDFPQISYMISAWARMCKILGKEFQQY
LPVVMGPLMKTASIKPEVALLDTQDMENMSDDDGWEFVNLGDQQSFGIKT
AGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYFHDGVRVA
AAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDVLSEIMHS
FAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDE
QVEESLQDEDDNDVYILTKVSDILHSIFSSYKEKVLPWFEQLLPLIVNLI
CPHRPWPDRQWGLCIFDDVIEHCSPASFKYAEYFLRPMLQYVCDNSPEVR
QAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENVNATENC
ISAVGKIMKFKPDCVNVEEVLPHWLSWLPLHEDKEEAVQTFNYLCDLIES
NHPIVLGPNNTNLPKIFSIIAEGEMHEAIKHEDPCAKRLANVVRQVQTSG
GLWTECIAQLSPEQQAAIQELLNSA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6xte X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking.
Resolution2.27 Å
Binding residue
(original residue number in PDB)		Y855 K859 W901 Q941 A942 Y945 N989 D1023 E1026
Binding residue
(residue number reindexed from 1)		Y815 K819 W861 Q901 A902 Y905 N949 D983 E986
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
GO:0008139 nuclear localization sequence binding
GO:0031267 small GTPase binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0002753 cytoplasmic pattern recognition receptor signaling pathway
GO:0006606 protein import into nucleus
GO:0006607 NLS-bearing protein import into nucleus
GO:0006610 ribosomal protein import into nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0042307 positive regulation of protein import into nucleus
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
GO:0031965 nuclear membrane

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6xte, PDBe:6xte, PDBj:6xte
PDBsum6xte
PubMed32222384
UniProtO00410|IPO5_HUMAN Importin-5 (Gene Name=IPO5)

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