Structure of PDB 6xrp Chain A Binding Site BS01

Receptor Information

>6xrp Chain A (length=180) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTH
ALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQK
FSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAGW
FDLFGMSMANGAHIAGLAVGLAMAFVDSLN

Ligand information

>6xrp Chain B (length=6) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ARVWHA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6xrp Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria.
Resolution	2.4 Å
Binding residue (original residue number in PDB)	F146 H150 S193 W196 F197 G198 G199 S201 M247 S248 M249 A250
Binding residue (residue number reindexed from 1)	F55 H59 S102 W105 F106 G107 G108 S110 M156 S157 M158 A159

Enzymatic activity

Enzyme Commision number

3.4.21.105: rhomboid protease.

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0016020	membrane

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Cellular Component

External links

PDB	RCSB:6xrp, PDBe:6xrp, PDBj:6xrp
PDBsum	6xrp
PubMed	32888502
UniProt	P09391\|GLPG_ECOLI Rhomboid protease GlpG (Gene Name=glpG)

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