Structure of PDB 6xqb Chain A Binding Site BS01

Receptor Information
>6xqb Chain A (length=801) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VYRAFDIYVAGFAKFLKRLTKYTMADLVYALRHFDEGNCDTLKEILVTYN
CCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAG
IVGVLTLDNQDLNGNWYDFGDFIQTGVPVVDSYYSLLMPILTLTRALTAE
SHVDTDLTKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDD
RCILHCANFNVLFSTVFPPTSFGPLVRKIFVDGVPFVVSTGYHFRELGVV
HNQDVNLHSSRLSFKELLVYAADPAMHAASGNLLLDKRTTCFSVAALTNN
VAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELKHFFFAQDGNAAISDYD
YYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNNLDKSAGF
PFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRA
RTVAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKT
VYSDVENPHLMGWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYR
LANECAQVLSEMVMCGGSLYVKPGGTSSGDATTAYANSVFNICQAVTANV
NALLSTIADKYVRNLQHRLYECLYRNRDVDTDFVNEFYAYLRKHFSMMIL
SDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNVFMSEAKCWTETDLTKG
PHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTDGTLMIER
FVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELMLTNDNTSRYWEP
E
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6xqb Structure of SARS-CoV-2 RdRp/RNA complex at 3.4 Angstroms resolution
Resolution3.4 Å
Binding residue
(original residue number in PDB)		L758 S759 D760 D761 C813 S814 R836 R858
Binding residue
(residue number reindexed from 1)		L650 S651 D652 D653 C705 S706 R728 R750
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6xqb, PDBe:6xqb, PDBj:6xqb
PDBsum6xqb
PubMed
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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