Structure of PDB 6xmt Chain A Binding Site BS01

Receptor Information
>6xmt Chain A (length=1092) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSFVSSPIVRDSTLLVPKSLIAKPYVLPFFPLYATFAQLYFEWTFVYLGT
LVSLNILVMLMPAWNVKIKAKFNYSTTKNVNEATHILIYTTPNNGSDGIV
EIQRVTEAGSLQTFFQFQKKRFLWHENEQVFSSPKFLVDESPKIGDFQKC
KGHSGDLTHLKRLYGENSFDIPIPTFMELFKEHAVAPLFVFQVFCVALWL
LDEFWYYSLFNLFMIISMEAAAVFQRLTALKEFRTMGIKPYTINVFRNKK
WVALQTNELLPMDLVSITRTAEESAIPCDLILLDGSAIVNEAMLSGESTP
LLKESIKLRPSEDNLQLDGVDKIAVLHGGTKALQVTPPEHKSDIPPPPDG
GALAIVTKTGFETSQGSLVRVMIYSAEDNKEALMFILFLLIFAVIASWYV
WVEGTKMGRIQSKLILDCILIITSVVPPELPMELTMAVNSSLAALAKFYV
YCTEPFRIPFAGRIDVCCFDKTGTLTGEDLVFEGLAGISADSENIRHLYS
AAEAPESTILVIGAAHALVKLEDGDIVGDPMEKATLKAVGWAVERKNSNY
REGTGKLDIIRRFQFSSALKRSASIASHNDALFAAVKGAPETIRERLSDI
PKNYDEIYKSFTRSGSRVLALASKSLPKDLNRDDVESELTFNGFLIFHCP
LKDDAIETIKMLNESSHRSIMITGDNPLTAVHVAKEVGIVFGETLILDRA
GKSDDNQLLFRDVEETVSIPFDPSKDTFDHSKLFDRYDIAVTGYALNALE
GHSQLRDLLRHTWVYARVSPSQKEFLLNTLKDMGYQTLMCGDGTNDVGAL
KQAHVGIALLNGTEEGLKKLGEQRRLEGMKAPALKLGDASCAAPFTSKLA
NVSAVTNIIRQGRCALVNTIQMYKILALNCLISAYSLSIIYMAGVKFGDG
QATVSGLLLSVCFLSISRGKPLEKLSKQRPQSGIFNVYIMGSILSQFAVH
IATLVYITTEIYKLEPREPQVDLEKEFAPSLLNTGIFIIQLVQQVSTFAV
NYQGEPFRENIRSNKGMYYGLLGVTGLALASATEFLPELNEAMKFVPMTD
DFKIKLTLTLLLDFFGSWGVEHFFKFFFMDDKPSDISVQQVK
Ligand information
Ligand IDBEF
InChIInChI=1S/Be.3FH/h;3*1H/q+2;;;/p-3
InChIKeyOGIAHMCCNXDTIE-UHFFFAOYSA-K
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[Be-](F)(F)F
ACDLabs 10.04
CACTVS 3.341		F[Be-](F)F
FormulaBe F3
NameBERYLLIUM TRIFLUORIDE ION
ChEMBL
DrugBank
ZINC
PDB chain6xmt Chain A Residue 1301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6xmt The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		D487 T489 K797
Binding residue
(residue number reindexed from 1)		D470 T472 K773
Annotation score1
Enzymatic activity
Enzyme Commision number 7.4.2.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015662 P-type ion transporter activity
GO:0016887 ATP hydrolysis activity
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity
GO:0046872 metal ion binding
GO:0070273 phosphatidylinositol-4-phosphate binding
GO:0140358 P-type transmembrane transporter activity
GO:0140567 membrane protein dislocase activity
Biological Process
GO:0006874 intracellular calcium ion homeostasis
GO:0015031 protein transport
GO:0030026 intracellular manganese ion homeostasis
GO:0034214 protein hexamerization
GO:0043335 protein unfolding
GO:0055085 transmembrane transport
GO:0055092 sterol homeostasis
GO:0098655 monoatomic cation transmembrane transport
GO:0140569 extraction of mislocalized protein from ER membrane
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005801 cis-Golgi network
GO:0016020 membrane

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6xmt, PDBe:6xmt, PDBj:6xmt
PDBsum6xmt
PubMed32973005
UniProtP39986|SPF1_YEAST Endoplasmic reticulum transmembrane helix translocase (Gene Name=SPF1)

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