Structure of PDB 6xh3 Chain A Binding Site BS01

Receptor Information
>6xh3 Chain A (length=88) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRPNHTIYINNLNSKIKKDELKKSLHAIFSRFGQILDILVPRTRRPRGQA
FVIFKEVSSATNALRSMQGFPFYDKPMAIQYAKTDRTI
Ligand information
>6xh3 Chain D (length=27) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggagaucugagccugggagcucucucc
<<<<<...<<<<......>>>>>>>>>
Receptor-Ligand Complex Structure
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PDB6xh3 Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors.
Resolution2.353 Å
Binding residue
(original residue number in PDB)		Y13 K20 K23 R47 R49 R50 R52 A87 K88
Binding residue
(residue number reindexed from 1)		Y8 K15 K18 R42 R44 R45 R47 A82 K83
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

View graph for
Molecular Function
External links
PDB RCSB:6xh3, PDBe:6xh3, PDBj:6xh3
PDBsum6xh3
PubMed33051202
UniProtP09012|SNRPA_HUMAN U1 small nuclear ribonucleoprotein A (Gene Name=SNRPA)

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