Structure of PDB 6x5u Chain A Binding Site BS01
Receptor Information
>6x5u Chain A (length=467) Species:
9606
(Homo sapiens) [
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LGKDHEILRRRIENGAKELWFFLQSELKKLKNLEGNELQRHADEFLLDLG
HHERSIMTDLYYLSQTDGAGDWREKEAKDLTELVQRRITYLQNPKDCSKA
KKLVCNINKGCGYGCQLHHVVYCFMIAYGTQRTLILESQNWRYATGGWET
VFRPVSETCTDRSGISTGHWSGEVKDKNVQVVELPIVDSLHPRPPYLPLA
VPEDLADRLVRVHGDPAVWWVSQFVKYLIRPQPWLEKEIEEATKKLGFKH
PVIGVHVRRTDKVGTEAAFHPIEEYMVHVEEHFQLLARRMQVDKKRVYLA
TDDPSLLKEAKTKYPNYEFISDNSISWSAGLHNRYTENSLRGVILDIHFL
SQADFLVCTFSSQVCRVAYEIMQTLHPDASANFHSLDDIYYFGGQNAHNQ
IAIYAHQPRTADEIPMEPGDIIGVAGNHWDGYSKGVNRKLGRTGLYPSYK
VREKIETVKYPTYPEAE
Ligand information
Ligand ID
GDP
InChI
InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKey
QGWNDRXFNXRZMB-UUOKFMHZSA-N
SMILES
Software
SMILES
OpenEye OEToolkits 1.7.6
c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.385
NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.385
NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 12.01
O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.7.6
c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
Formula
C10 H15 N5 O11 P2
Name
GUANOSINE-5'-DIPHOSPHATE
ChEMBL
CHEMBL384759
DrugBank
DB04315
ZINC
ZINC000008215481
PDB chain
6x5u Chain A Residue 600 [
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Receptor-Ligand Complex Structure
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PDB
6x5u
Characterizing human alpha-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases.
Resolution
3.2 Å
Binding residue
(original residue number in PDB)
G219 Y220 G221 C222 Y250 H363 R365 K369 A407 T408 D409 A436 R441 V450 D453 S469 Q470 V471
Binding residue
(residue number reindexed from 1)
G112 Y113 G114 C115 Y143 H256 R258 K262 A300 T301 D302 A329 R334 V343 D346 S362 Q363 V364
Annotation score
4
Enzymatic activity
Enzyme Commision number
2.4.1.68
: glycoprotein 6-alpha-L-fucosyltransferase.
Gene Ontology
Molecular Function
GO:0005515
protein binding
GO:0008424
glycoprotein 6-alpha-L-fucosyltransferase activity
GO:0016757
glycosyltransferase activity
GO:0017124
SH3 domain binding
GO:0046921
alpha-(1->6)-fucosyltransferase activity
Biological Process
GO:0001701
in utero embryonic development
GO:0006486
protein glycosylation
GO:0006487
protein N-linked glycosylation
GO:0006491
N-glycan processing
GO:0007179
transforming growth factor beta receptor signaling pathway
GO:0007229
integrin-mediated signaling pathway
GO:0007585
respiratory gaseous exchange by respiratory system
GO:0009312
oligosaccharide biosynthetic process
GO:0010468
regulation of gene expression
GO:0010761
fibroblast migration
GO:0016477
cell migration
GO:0018279
protein N-linked glycosylation via asparagine
GO:0019082
viral protein processing
GO:0036071
N-glycan fucosylation
GO:0042355
L-fucose catabolic process
GO:0043112
receptor metabolic process
GO:0046368
GDP-L-fucose metabolic process
GO:1900407
regulation of cellular response to oxidative stress
Cellular Component
GO:0000139
Golgi membrane
GO:0005794
Golgi apparatus
GO:0016020
membrane
GO:0032580
Golgi cisterna membrane
GO:0070062
extracellular exosome
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:6x5u
,
PDBe:6x5u
,
PDBj:6x5u
PDBsum
6x5u
PubMed
33004438
UniProt
Q9BYC5
|FUT8_HUMAN Alpha-(1,6)-fucosyltransferase (Gene Name=FUT8)
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