Structure of PDB 6x3m Chain A Binding Site BS01

Receptor Information
>6x3m Chain A (length=361) Species: 12366 (Streptococcus pyogenes phage H4489A) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LRVQFKRMSADEWARSDVILLEGEIGFETDTGFAKFGDGQNTFSKLKYLT
GPKGPKGDTGLQGKTGGTGPRGPAGKPGTTDYDQLQNKPDLGAFAQKEET
NSKITKLESSKADKSAVYSKAESKIELDKKLSLTGGIVTGQLQFKPNKSG
IKPSSSVGGAINIDMSKSEGAAMVMYTNKDTTDGPLMILRSDKDTFDQSA
QFVDYSGKTNAVNIVMRQPSAPNFSSALNITSANEGGSAMQIRGVEKALG
TLKITHENPNVEAKYDENAAALSIDIVKKQKGGKGTAAQGIYINSTSGTA
GKMLRIRNKNEDKFYVGPDGGFHSGANSTVAGNLTVKDPTSGKHAATKDY
VDEKIAELKKL
Ligand information
Ligand IDBDP
InChIInChI=1S/C6H10O7/c7-1-2(8)4(5(10)11)13-6(12)3(1)9/h1-4,6-9,12H,(H,10,11)/t1-,2-,3+,4-,6+/m0/s1
InChIKeyAEMOLEFTQBMNLQ-QIUUJYRFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0[C@@H]1([C@@H]([C@H](O[C@H]([C@@H]1O)O)C(=O)O)O)O
OpenEye OEToolkits 1.7.0C1(C(C(OC(C1O)O)C(=O)O)O)O
CACTVS 3.370O[CH]1O[CH]([CH](O)[CH](O)[CH]1O)C(O)=O
ACDLabs 12.01O=C(O)C1OC(O)C(O)C(O)C1O
CACTVS 3.370O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O
FormulaC6 H10 O7
Namebeta-D-glucopyranuronic acid;
beta-D-glucuronic acid;
D-glucuronic acid;
glucuronic acid
ChEMBLCHEMBL1159524
DrugBankDB03156
ZINCZINC000004097543
PDB chain6x3m Chain O Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6x3m Crystal Structure of Streptococcal Bacteriophage Hyaluronidase: Presence of a Prokaryotic Collagen and Elucidation of Catalytic Mechanism
Resolution3.581 Å
Binding residue
(original residue number in PDB)		Q295 Y298
Binding residue
(residue number reindexed from 1)		Q289 Y292
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.1.35: hyaluronoglucosaminidase.
Gene Ontology
Molecular Function
GO:0004415 hyalurononglucosaminidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0045227 capsule polysaccharide biosynthetic process
GO:0046718 symbiont entry into host cell
GO:0098994 symbiont entry into host cell via disruption of host cell envelope
GO:0098996 symbiont entry into host cell via disruption of host cell glycocalyx
Cellular Component
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6x3m, PDBe:6x3m, PDBj:6x3m
PDBsum6x3m
PubMed
UniProtP15316|HYLP1_BPH44 Hyaluronoglucosaminidase (Gene Name=HYLP1)

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