Structure of PDB 6x26 Chain A Binding Site BS01

Receptor Information
>6x26 Chain A (length=1142) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RYTLPVKAGEQRLLGELTGAACATLVAEIAERHAGPVVLIAPDMQNALRL
HDEISQFTDQMVMNLADWETLPYDSFSPHQDIISSRLSTLYQLPTMQRGV
LIVPVNTLMQRVCPHSFLHGHALVMKKGQRLSRDALRTQLDSAGYRHVDQ
VMEHGEYATRGALLDLFPMGSELPYRLDFFDDEIDSLRVFDVDSQRTLEE
VEAINLLPAHEFPTDKAAIELFRSQWRDTFEVKRDPEHIYQQVSKGTLPA
GIEYWQPLFFSEPLPPLFSYFPANTLLVNTGDLETSAERFQADTLARFEN
RGVDPMRPLLPPQSLWLRVDELFSELKNWPRVQLKTEHLPTKAANANLGF
QKLPDLAVQAQQKAPLDALRKFLETFDGPVVFSVESEGRREALGELLARI
KIAPQRIMRLDEASDRGRYLMIGAAEHGFVDTVRNLALICESDLLGERVA
RRRQDSRRTINPDTLIRNLAELHIGQPVVHLEHGVGRYAGMTTLEAGGIT
GEYLMLTYANDAKLYVPVSSLHLISRYAGGAEENAPLHKLGGDAWSRARQ
KAAEKVRDVAAELLDIYAQRAAKEGFAFKHDREQYQLFCDSFPFETTPDQ
AQAINAVLSDMCQPLAMDRLVCGDVGFGKTEVAMRAAFLAVDNHKQVAVL
VPTTLLAQQHYDNFRDRFANWPVRIEMISRFRSAKEQTQILAEVAEGKID
ILIGTHKLLQSDVKFKDLGLLIVDEEHRFGVRHKERIKAMRANVDILTLT
ATPIPRTLNMAMSGMRDLSIIATPPARRLAVKTFVREYDSMVVREAILRE
ILRGGQVYYLYNDVENIQKAAERLAELVPEARIAIGHGQMRERELERVMN
DFHHQRFNVLVCTTIIETGIDIPTANTIIIERADHFGLAQLHQLRGRVGR
SHHQAYAWLLTPHPKAMTTDAQKRLEAIASLEDLGAGFALATHDLEIRGA
GELLGEEQSGSMETIGFSLYMELLENAVDALKAGREPSLEDLTSQQTEVE
LRMPSLLPDDFIPDVNTRLSFYKRIASAKTENELEEIKVELIDRFGLLPD
PARTLLDIARLRQQAQKLGIRKLEGNEKGGVIEFAEKNHVNPAWLIGLLQ
KQPQHYRLDGPTRLKFIQDLSERKTRIEWVRQFMRELEENAI
Ligand information
>6x26 Chain P (length=55) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gggtattcgccgcgtacctctcctagcccgcaagtatcctattccttgca
gcggt
Receptor-Ligand Complex Structure
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PDB6x26 Structural basis for transcription complex disruption by the Mfd translocase.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		T658 T659 R685 T710 H711 K712 Q715 N817 I870
Binding residue
(residue number reindexed from 1)		T653 T654 R680 T705 H706 K707 Q710 N812 I865
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015616 DNA translocase activity
GO:0016787 hydrolase activity
GO:0043175 RNA polymerase core enzyme binding
Biological Process
GO:0000716 transcription-coupled nucleotide-excision repair, DNA damage recognition
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006294 nucleotide-excision repair, preincision complex assembly
GO:0006355 regulation of DNA-templated transcription
GO:0006974 DNA damage response
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1990391 DNA repair complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6x26, PDBe:6x26, PDBj:6x26
PDBsum6x26
PubMed33480355
UniProtP30958|MFD_ECOLI Transcription-repair-coupling factor (Gene Name=mfd)

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