Structure of PDB 6ww7 Chain A Binding Site BS01

Receptor Information

>6ww7 Chain A (length=927) Species: 9606 (Homo sapiens)

EDQVGKFDWRQQYVGKVKFASLEFSPGSKKLVVATEKNVIAALNSRTGEI
LWRHVDKGTAEGAVDAMLLHGQDVITVSNGGRIMRSWETNIGGLNWEITL
DSGSFQALGLVGLQESVRYIAVLKKTTLALHHLSSGHLKWVEHLPESDSI
HYQMVYSYGSGVVWALGVVPFSHVNIVKFNVEDGEIVQQVRVSTPWLQHL
SGACGVVDEAVLVCPDPSSRSLQTLALETEWELRQIPLQSLDLEFGSGFQ
PRVLPTQPNPVDASRAQFFLHLSPSHYALLQYHYGTLSLLKNFPQTALVS
FATTGEKTVAAVMACRNEACFNQTYTINLYLVETGRRLLDTTITFSLEQS
GTRPERLYIQVFLKKDDSVGYRALVQTEDHLLLFLQQLAGKVVLWSREES
LAEVVCLEMVDLPLTGAQAELEGEFGKKADGLLGMFLKRLSSQLILLQAW
TSHLNIDTLARDEFNLQKMMVMVTASGKLFGIESSSGTILWKQYLPNVKP
DSSFKLMVQRTTAHFPHPPQCTLLVKDKESGMSSLYVFNPIFGKWSQVAP
PVLKRPILQSLLLPVMDQDYAKVLLLIDDEYKVTAFPATRNVLRQLHELA
PSIFFYLVDAEQGRLCGYRLRKDLTTELSWELTIPPEVQRIVKVKGKRSS
EHVHSQGRVMGDRSVLYKSLNPNLLAVVTESTDAHHERTFIGIFLIDGVT
GRIIHSSVQKKAKGPVHIVHSENWVVYQYWNTKARRNEFTVLELYEGTEQ
YNATAFSSLDRPQLPQVLQQSYIFPSSISAMEATITERGITSRHLLIGLP
SGAILSLPKALLDPRRPEIPTEQSREENLIPYSPDVQIHAERFINYNQTV
SRMRGIYTAPSGLESTCLVVAYGLDIYQTRVYPSKQFDVLKDDYDYVLIS
SVLFGLVFATMITKRLAQVKLLNRAWR

Ligand information

>6ww7 Chain D (length=14) Species: 9606 (Homo sapiens)

AAAAAAAAGGGAAA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ww7 Structural basis for membrane insertion by the human ER membrane protein complex.
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): K592 L624 Q625 S668 I669 F670 Y672 V674 N739 T820 A821 F822
• Binding residue (residue number reindexed from 1): K526 L558 Q559 S602 I603 F604 Y606 V608 N673 T754 A755 F756

Gene Ontology

Cellular Component

• GO:0072546 EMC complex

External links

• PDB: RCSB:6ww7, PDBe:6ww7, PDBj:6ww7
• PDBsum: 6ww7
• PubMed: 32439656
• UniProt: Q8N766|EMC1_HUMAN ER membrane protein complex subunit 1 (Gene Name=EMC1)