Structure of PDB 6wu5 Chain A Binding Site BS01

Receptor Information
>6wu5 Chain A (length=181) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QTVFTHEQLEAYQDCTFFTRKEIMRLFYRYQDLAPQLVPLDYTTCPDVKV
PYELIGSMPELKDNPFRQRIAQVFSEDGDGHMTLDNFLDMFSVMSEMAPR
DLKAYYAFKIYDFNNDDYICAWDLEQTVTKLTRGELSAEEVSLVCEKVLD
EADGDHDGRLSLEDFQNMILRAPDFLSTFHI
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6wu5 Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6wu5 CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells.
Resolution1.88 Å
Binding residue
(original residue number in PDB)		D116 N118 D120 Y122 D127
Binding residue
(residue number reindexed from 1)		D112 N114 D116 Y118 D123
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0055074 calcium ion homeostasis

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Molecular Function
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Biological Process
External links
PDB RCSB:6wu5, PDBe:6wu5, PDBj:6wu5
PDBsum6wu5
PubMed34089643
UniProtQ96Q77|CIB3_HUMAN Calcium and integrin-binding family member 3 (Gene Name=CIB3)

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