Structure of PDB 6wth Chain A Binding Site BS01
Receptor Information
>6wth Chain A (length=381) Species:
9606
(Homo sapiens) [
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VSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYK
YSSTLPHPLQRLKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINIL
SRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFND
KNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPA
FMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSK
YTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKL
QVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQN
NYTVNNKRNGVAKVNIFFKELNYKTNSESPS
Ligand information
Ligand ID
NA
InChI
InChI=1S/Na/q+1
InChIKey
FKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0
[Na+]
Formula
Na
Name
SODIUM ION
ChEMBL
DrugBank
DB14516
ZINC
PDB chain
6wth Chain A Residue 700 [
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Receptor-Ligand Complex Structure
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PDB
6wth
Molecular principles of assembly, activation, and inhibition in epithelial sodium channel.
Resolution
3.06 Å
Binding residue
(original residue number in PDB)
L135 N136 D338 V346 T347
Binding residue
(residue number reindexed from 1)
L22 N23 D178 V186 T187
Annotation score
5
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0005272
sodium channel activity
GO:0005515
protein binding
GO:0015280
ligand-gated sodium channel activity
GO:0050699
WW domain binding
Biological Process
GO:0006814
sodium ion transport
GO:0006883
intracellular sodium ion homeostasis
GO:0008217
regulation of blood pressure
GO:0034220
monoatomic ion transmembrane transport
GO:0035725
sodium ion transmembrane transport
GO:0050891
multicellular organismal-level water homeostasis
GO:0050909
sensory perception of taste
GO:0050914
sensory perception of salty taste
GO:0050915
sensory perception of sour taste
GO:0055078
sodium ion homeostasis
GO:0071468
cellular response to acidic pH
GO:0098662
inorganic cation transmembrane transport
GO:0098719
sodium ion import across plasma membrane
GO:1904045
cellular response to aldosterone
GO:1904117
cellular response to vasopressin
Cellular Component
GO:0001669
acrosomal vesicle
GO:0005737
cytoplasm
GO:0005829
cytosol
GO:0005886
plasma membrane
GO:0009897
external side of plasma membrane
GO:0016020
membrane
GO:0016324
apical plasma membrane
GO:0031410
cytoplasmic vesicle
GO:0031514
motile cilium
GO:0034706
sodium channel complex
GO:0060170
ciliary membrane
GO:0070062
extracellular exosome
GO:0097228
sperm principal piece
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:6wth
,
PDBe:6wth
,
PDBj:6wth
PDBsum
6wth
PubMed
32729833
UniProt
P37088
|SCNNA_HUMAN Amiloride-sensitive sodium channel subunit alpha (Gene Name=SCNN1A)
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