Structure of PDB 6wth Chain A Binding Site BS01

Receptor Information
>6wth Chain A (length=381) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSLNINLNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYK
YSSTLPHPLQRLKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINIL
SRLPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFND
KNNSNLWMSSMPGINNGLSLMLRAEQNDFIPLLSTVTGARVMVHGQDEPA
FMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDVPVENLYPSK
YTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKL
QVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQN
NYTVNNKRNGVAKVNIFFKELNYKTNSESPS
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0
[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain6wth Chain A Residue 700 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6wth Molecular principles of assembly, activation, and inhibition in epithelial sodium channel.
Resolution3.06 Å
Binding residue
(original residue number in PDB)
L135 N136 D338 V346 T347
Binding residue
(residue number reindexed from 1)
L22 N23 D178 V186 T187
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005272 sodium channel activity
GO:0005515 protein binding
GO:0015280 ligand-gated sodium channel activity
GO:0050699 WW domain binding
Biological Process
GO:0006814 sodium ion transport
GO:0006883 intracellular sodium ion homeostasis
GO:0008217 regulation of blood pressure
GO:0034220 monoatomic ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0050891 multicellular organismal-level water homeostasis
GO:0050909 sensory perception of taste
GO:0050914 sensory perception of salty taste
GO:0050915 sensory perception of sour taste
GO:0055078 sodium ion homeostasis
GO:0071468 cellular response to acidic pH
GO:0098662 inorganic cation transmembrane transport
GO:0098719 sodium ion import across plasma membrane
GO:1904045 cellular response to aldosterone
GO:1904117 cellular response to vasopressin
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0031514 motile cilium
GO:0034706 sodium channel complex
GO:0060170 ciliary membrane
GO:0070062 extracellular exosome
GO:0097228 sperm principal piece

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:6wth, PDBe:6wth, PDBj:6wth
PDBsum6wth
PubMed32729833
UniProtP37088|SCNNA_HUMAN Amiloride-sensitive sodium channel subunit alpha (Gene Name=SCNN1A)

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