Structure of PDB 6wtb Chain A Binding Site BS01

Receptor Information
>6wtb Chain A (length=537) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRGANVIWFRHGLRLHDNPALLAALADKDQGIALIPVFIFDGESAGTKNV
GYNRMRFLLDSLQDIDDQLQAATDGRGRLLVFEGEPAYIFRRLHEQVRLH
RICIEQDCEPIWNERDESIRSLCRELNIDFVEKVSHTLWDPQLVIETNGG
IPPLTYQMFLHTVQIIGLPPRPTADARLEDATFVELDPEFCRSLKLFEQL
PTPEHFNVYGDNMGFLAKINWRGGETQALLLLDERLKVEQHAFERGFYLP
NQALPNIHDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLRACVRGVQM
TGGAHITGQLIWREYFYTMSVNNPNYDRMEGNDICLSIPWAKPNENLLQS
WRLGQTGFPLIDGAMRQLLAEGWLHHTLRNTVATFLTRGGLWQSWEHGLQ
HFLKYLLDADWSVCAGNWMWVSSSAFERLLDSSLVTCPVALAKRLDPDGT
YIKQYVPELMNVPKEFVHEPWRMSAEQQEQYECLIGVHYPERIIDLSMAV
KRNMLAMKSLRNSLITPPPHCRPSNEEEVRQFFWLAD
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6wtb Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6wtb Tuning flavin environment to detect and control light-induced conformational switching in Drosophila cryptochrome.
Resolution2.58 Å
Binding residue
(original residue number in PDB)		S265 M266
Binding residue
(residue number reindexed from 1)		S263 M264
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) Q311 W314 W342 H378 W397 W420
Catalytic site (residue number reindexed from 1) Q309 W312 W340 H376 W395 W418
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003913 DNA photolyase activity
GO:0005515 protein binding
GO:0009881 photoreceptor activity
GO:0009882 blue light photoreceptor activity
GO:0050660 flavin adenine dinucleotide binding
GO:0071949 FAD binding
Biological Process
GO:0007602 phototransduction
GO:0007623 circadian rhythm
GO:0009416 response to light stimulus
GO:0009588 UV-A, blue light phototransduction
GO:0009637 response to blue light
GO:0009649 entrainment of circadian clock
GO:0009785 blue light signaling pathway
GO:0032922 circadian regulation of gene expression
GO:0042332 gravitaxis
GO:0042752 regulation of circadian rhythm
GO:0043153 entrainment of circadian clock by photoperiod
GO:0045187 regulation of circadian sleep/wake cycle, sleep
GO:0045475 locomotor rhythm
GO:0045892 negative regulation of DNA-templated transcription
GO:0048511 rhythmic process
GO:0048512 circadian behavior
GO:0050958 magnetoreception
GO:0050980 detection of light stimulus involved in magnetoreception
GO:0071000 response to magnetism
GO:0071482 cellular response to light stimulus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wtb, PDBe:6wtb, PDBj:6wtb
PDBsum6wtb
PubMed33637846
UniProtO77059|CRY1_DROME Cryptochrome-1 (Gene Name=cry)

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