Structure of PDB 6wre Chain A Binding Site BS01

Receptor Information

>6wre Chain A (length=358) Species: 10090 (Mus musculus)

PSLRTQPSLYSGPFPFYRRPSELGCFSLDAQRQYHGDARALRYYSPPPIN
GPGPDFDLRDGYPDRYQPRDEEVQERLDHLLRWVLEHRNQLEGGPGWLAG
ATVTWRGHLTKLLTTPYERQEGWQLAASRFQGTLYLSEVETPAARAQRLA
RPPLLRELMYMGYKFEQYMCADKPGGSPDPSGEVNTNVAYCSVLRSRLGN
HPLLFSGEVDCLNPQAPCTQPPSCYVELKTSKEMHSPGQWRSFYRHKLLK
WWAQSFLPGVPHVVAGFRNPEGFVCSLKTFPTMEMFENVRNDREGWNPSV
CMNFCAAFLSFAQSTVVQDDPRLVHLFSWEPGGPVTVSVHRDAPYAFLPS
WYVETMTQ

Ligand information

>6wre Chain D (length=5)

uuuuu

.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6wre A novel 5'-hydroxyl dinucleotide hydrolase activity for the DXO/Rai1 family of enzymes.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): R95 E101 R102 W131 R132 G133 H134 L184 M185 G188 Y189 E234 K255 T256 K273 R294
• Binding residue (residue number reindexed from 1): R69 E75 R76 W105 R106 G107 H108 L158 M159 G162 Y163 E208 K229 T230 K247 R268

Enzymatic activity

• Enzyme Commision number: 3.1.13.-
  3.6.1.-

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0000287 magnesium ion binding
• GO:0003723 RNA binding
• GO:0003729 mRNA binding
• GO:0004527 exonuclease activity
• GO:0008409 5'-3' exonuclease activity
• GO:0034353 mRNA 5'-diphosphatase activity
• GO:0046872 metal ion binding
• GO:0110152 RNA NAD+-cap (NAD+-forming) hydrolase activity

Biological Process

• GO:0006402 mRNA catabolic process
• GO:0050779 RNA destabilization
• GO:0071028 nuclear mRNA surveillance
• GO:0090304 nucleic acid metabolic process
• GO:0110155 NAD-cap decapping

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:6wre, PDBe:6wre, PDBj:6wre
• PDBsum: 6wre
• PubMed: 31777937
• UniProt: O70348|DXO_MOUSE Decapping and exoribonuclease protein (Gene Name=Dxo)