Structure of PDB 6wm5 Chain A Binding Site BS01

Receptor Information

>6wm5 Chain A (length=337) Species: 224325,557599

MRLAYVKNHEIYGEKLLGLTLRERIEKTLQRAGFDVRFFDELSLEEAEDY
LIILEPVLILERDLLLEGRKILVSDGFTVGYFFGGDFRTVFDGNLQSSIE
KYLSLNNLESYEIWAIKLSNDNLKTAEKLLLSSLISRAAFARITLPLARA
LLRIGLTPDAVTIIGTTASVAGALVLFPMGKLFPGACVVWFFVLFDMLDG
AMARLRSGGTRFGAVLDAACDRISDGAVFSGLLWWIAFGMRDRLLVVATL
TCLVTSQVISYIKARAEASGLRGDGGIIERPERLIIVLVGAGVSDFPFIA
WPPALPVAMWVLAVASVITLGQRLHTVWTSPGATDRI

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 6wm5 Chain A Residue 306

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6wm5 Structural and Functional Characterization of Phosphatidylinositol-Phosphate Biosynthesis in Mycobacteria.
• Resolution: 1.961 Å
• Binding residue (original residue number in PDB): S128 I131 S132 R152 R155
• Binding residue (residue number reindexed from 1): S256 I259 S260 R280 R283
• Annotation score: 3

Enzymatic activity

• Enzyme Commision number:
  2.7.8.-

Gene Ontology

Molecular Function

• GO:0016780 phosphotransferase activity, for other substituted phosphate groups

Biological Process

• GO:0008654 phospholipid biosynthetic process

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6wm5, PDBe:6wm5, PDBj:6wm5
• PDBsum: 6wm5
• PubMed: 32389689
• UniProt: O27985;
  U5WZP7