Structure of PDB 6wk6 Chain A Binding Site BS01

Receptor Information
>6wk6 Chain A (length=427) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAV
SYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVM
EIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGL
PQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIE
RETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKI
RSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGI
EHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKD
RNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKN
CNTSGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6wk6 Structural insights into the bypass of the major deaminated purines by translesion synthesis DNA polymerase.
Resolution2.35 Å
Binding residue
(original residue number in PDB)		Q38 Y39 W42 G46 I47 I48 R61 S62 W64 K86 K293 K311 P316 K317 T318 G320 S322 K323 N324 P326
Binding residue
(residue number reindexed from 1)		Q38 Y39 W42 G46 I47 I48 R61 S62 W64 K86 K288 K306 P311 K312 T313 G315 S317 K318 N319 P321
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6wk6, PDBe:6wk6, PDBj:6wk6
PDBsum6wk6
PubMed33258913
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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