Structure of PDB 6whz Chain A Binding Site BS01

Receptor Information
>6whz Chain A (length=372) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKM
EIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCP
VFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFC
YVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY
GEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEM
YQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGG
GYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMT
NQNTPEYMEKIKQRLFENLRML
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6whz Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		E103 D104 H146 G154 F155 H183 F210 Y308
Binding residue
(residue number reindexed from 1)		E97 D98 H140 G148 F149 H177 F204 Y302
Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.98: histone deacetylase.
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity

View graph for
Molecular Function
External links
PDB RCSB:6whz, PDBe:6whz, PDBj:6whz
PDBsum6whz
PubMed34099674
UniProtQ92769|HDAC2_HUMAN Histone deacetylase 2 (Gene Name=HDAC2)

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