Structure of PDB 6wb6 Chain A Binding Site BS01

Receptor Information
>6wb6 Chain A (length=653) Species: 7130 (Manduca sexta) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSYKLCVPAAYMKDCEQMLEVPTKSKVALECVPARDRVECLSFVQQRQAD
FVPVDPEDMYVASKIPNQDFVVFQEYRTDEEPDAPFRYEAVIVVHKDLPI
NNLDQLKGLRSCHTGVNRNVGYKIPLTMLMKRAVFPKMNDHSISPKENEL
KALSTFFAKSCIVGKWSPDPKTNSAWKSQYSHLCSMCEHPERCDYPDNYS
GYEGALRCLAHNNGEVAFTKVIFTRKFFGLPVGTTPASPSNENPEEFRYL
CVDGSKAPITGKACSWAARPWQGLIGHNDVLAKLAPLREKVKQLADSGAA
DKPEWFTKVLGLSEKIHHVADNIPIKPIDYLNKANYTEVIERGHGAPELV
VRLCVTSNVALSKCRAMSVFAFSRDIRPILDCVQENSEDACLKSVQDNGS
DLASVDDMRVAAAAKKYNLHPVFHEVYGELKTPNYAVAVVKKGTAYNKID
DLRGKKSCHSSYSTFSGLHAPLFYLINKRAIQSDHCVKNLGEFFSGGSCL
PGVDKDDVSKLKKQCGSDSSAWKCLEEDRGDVAFVSSADLSHFDANQYEL
LCLNRDAGGRDVLSSFATCNVAMAPSRTWVAAKDFLSDVSIAHTPLSLAQ
MLATRPDLFNIYGEFLKNNNVIFNNAAKGLATTEKLDFEKFKTIHDVISS
CGL
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain6wb6 Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6wb6 Structural insight into the novel iron-coordination and domain interactions of transferrin-1 from a model insect, Manduca sexta.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		Y90 Y204
Binding residue
(residue number reindexed from 1)		Y88 Y202
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0046872 metal ion binding
Biological Process
GO:0006826 iron ion transport
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0055037 recycling endosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wb6, PDBe:6wb6, PDBj:6wb6
PDBsum6wb6
PubMed33197096
UniProtP22297|TRF_MANSE Transferrin

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