Structure of PDB 6w9m Chain A Binding Site BS01

Receptor Information
>6w9m Chain A (length=251) Species: 32630 (synthetic construct) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEFPTLISLLEVIEPEVLYSGYDSTLPDTSTRLMSTLNRLGGRQVVSAVK
WAKALPGFRNLHLDDQMTLLQYSWMSLMAFSLGWRSYKQSNGNMLCFAPD
LVINEERMQLPYMYDQCQQMLKISSEFVRLQVSYDEYLCMKVLLLLSTVP
KDGLKSQAVFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMH
EMVGGLLQFCFYTFVNKSLSVEFPEMLAEIISNQLPKFKAGSVKPLLFHQ
K
Ligand information
Receptor-Ligand Complex Structure
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PDB6w9m Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment.
Resolution1.59 Å
Binding residue
(original residue number in PDB)		V44 K48 L58 M62 Q66 E224 N228
Binding residue
(residue number reindexed from 1)		V49 K53 L63 M67 Q71 E229 N233
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0034056 estrogen response element binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030518 nuclear receptor-mediated steroid hormone signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:6w9m, PDBe:6w9m, PDBj:6w9m
PDBsum6w9m
PubMed32917814
UniProtA0A1X8XLE9

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