Structure of PDB 6w8v Chain A Binding Site BS01

Receptor Information
>6w8v Chain A (length=831) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DRISWLGQPMKIEENRTYYQKVSIDEEMLEVGDCVSVIPDDSSKPLYLAR
VTALWEDKNGQMMFHAHWFCAGTDTVLGATSDPLELFLVGECENMQLSYI
HSKVKVIYKAPSENWAMEGGEDGKTYFFQLWYNQEYARFESPPKTQPTED
NKHKFCLSCIRLAELRQKEMPKVLEQIEEVDGRVYCSSITKNGVVYRLGD
SVYLPPEAFTFNIKVASPVKRPKKDPVNETLYPEHYRKYSDYIKGSNLDA
PEPYRIGRIKEIHCGKKKGKVNEADIKLRLYKFYRPENTHRSYNGSYHTD
INMLYWSDEEAVVNFSDVQGRCTVEYGEDLLESIQDYSQGGPDRFYFLEA
YNSKTKNFEDPPNHARSPGNKLPKLRTLDVFSGCGGLSEGFHQAGISETL
WAIEMWDPAAQAFRLNNPGTTVFTEDCNVLLKLVMAGEVTNSLGQRLPQK
GDVEMLCGGPPCQGFSGMNRFNSYSKFKNSLVVSFLSYCDYYRPRFFLLE
NVRNFVSYRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIIL
AAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTIT
VRDTMSDLPEIQNGASNSEIPYNGEPLSWFQRQLRGSHYQPILRDHICKD
MSPLVAARMRHIPLFPGSDWRDLPNIQVRLGDGVIAHKLQYTFHDVKNGY
SSTGALRGVCSCAEGKACDPESRQFSTLIPWCLPHTGNRHNHWAGLYGRL
EWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDSYRFFG
NILDRHRQVGNAVPPPLAKAIGLEIKLCLLS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6w8v DNMT1 activity, base flipping mechanism and genome-wide DNA methylation are regulated by the DNA sequence context
Resolution3.12 Å
Binding residue
(original residue number in PDB)		G1234 R1237 R1272 S1276 Q1343 R1427 R1492 C1501 H1504 T1505 R1508 H1509 W1512 M1535
Binding residue
(residue number reindexed from 1)		G467 R470 R503 S507 Q574 R658 R723 C732 H735 T736 R739 H740 W743 M766
Enzymatic activity
Catalytic site (original residue number in PDB) C1229 E1269 R1313 R1315
Catalytic site (residue number reindexed from 1) C462 E500 R544 R546
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6w8v, PDBe:6w8v, PDBj:6w8v
PDBsum6w8v
PubMed
UniProtP13864|DNMT1_MOUSE DNA (cytosine-5)-methyltransferase 1 (Gene Name=Dnmt1)

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