Structure of PDB 6w5x Chain A Binding Site BS01

Receptor Information
>6w5x Chain A (length=427) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAV
SYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVM
EIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGL
PQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIE
RETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKI
RSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGI
EHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKD
RNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKN
CNTSGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6w5x Crystal structure of human polymerase eta complexed with N7-benzylguanine and dCTP*
Resolution2.59 Å
Binding residue
(original residue number in PDB)		Q38 Y39 W42 G46 I47 I48 S62 W64 K86 K311 R313 P316 K317 T318 G320 S322 K323 N324 P326 T329
Binding residue
(residue number reindexed from 1)		Q38 Y39 W42 G46 I47 I48 S62 W64 K86 K306 R308 P311 K312 T313 G315 S317 K318 N319 P321 T324
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6w5x, PDBe:6w5x, PDBj:6w5x
PDBsum6w5x
PubMed
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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