Structure of PDB 6w25 Chain A Binding Site BS01

Receptor Information
>6w25 Chain A (length=468) Species: 9606,272844 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLFVSPVVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADML
VSVSLGFETIVITLLNSTDAQSFTVNIDNVIDSVICASLLASICSLLSIA
VDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVI
ICLITMFFTMLALMASLYVHMFLMARLHGIDCSFWNESYLTGSRDERKKS
LLSKFGMDEGVTFMFIGRFDRGQKGVDVLLKAIEILSSKKEFQEMRFIII
GKGDPELEGWARSLEEKHGNVKVITEMLSREFVRELYGSVDFVIIPSYFE
PFGLVALEAMCLGAIPIASAVGGLRDIITNETGILVKAGDPGELANAILK
ALELSRSDLSKFRENCKKRAMSFSRQGANMKGAITLTILIGVFVVCWAPF
FLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIINPLIYALRSQELRK
TFKEIICCYEFLEVLFQG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6w25 Determination of the melanocortin-4 receptor structure identifies Ca2+as a cofactor for ligand binding.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		E100 T101 I104 D122 D126 I129 C130 L133 I185 S188 I194 F261 H264 L265 Y268 F284 L288
Binding residue
(residue number reindexed from 1)		E58 T59 I62 D78 D82 I85 C86 L89 I141 S144 I150 F400 H403 L404 Y407 F423 L427
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004977 melanocortin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6w25, PDBe:6w25, PDBj:6w25
PDBsum6w25
PubMed32327598
UniProtP32245|MC4R_HUMAN Melanocortin receptor 4 (Gene Name=MC4R);
Q9V2J8

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