Structure of PDB 6w23 Chain A Binding Site BS01

Receptor Information
>6w23 Chain A (length=552) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MENFTTNLNQLARVGGIDPLIGREKELERAIQVLCRRRKNNPLLVGESGV
GKTAIAEGLAWRIVQGDVPEVMADCTIYSLDIGSLLAGTKYRGDFEKRFK
ALLKQLEQDTNSILFIDEIHTIIGAANLIKPLLSSGKIRVIGSTTYQEFS
NIFEKDRALARRFQKIDITEPSIEETVQIINGLKPKYEAHHDVRYTAKAV
RAAVELAVKYINDRHLPDKAIDVIDEAGARARLMPVSKRKKTVNVADIES
VVARIARIPEKSVSQSDRDTLKNLGDRLKMLVFGQDKAIEALTEAIKMAR
AGLGHEHKPVGSFLFAGPTGVGKTEVTVQLSKALGIELLRFDMSEYMERH
TVSRLIGAPPGYVGFDQGGLLTDAVIKHPHAVLLLDEIEKAHPDVFNILL
QVMDNGTLTDNNGRKADFRNVVLVMTTNAGSTDAMEEIKKIFTPEFRNRL
DNIIWFDHLSTDVIHQVVDKFIVELQVQLDQKGVSLEVSQEARNWLAEKG
YDRAMGARPMARVIQDNLKKPLANELLFGSLVDGGQVTVALDKEKNELTY
GF
Ligand information
>6w23 Chain X (length=24) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
AAAAAAAAAAAAAAAAAAAAAAAA
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6w23 Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		Y259 R260 G539 Y540 V541
Binding residue
(residue number reindexed from 1)		Y91 R92 G361 Y362 V363
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006508 proteolysis
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
GO:0006979 response to oxidative stress
GO:0034605 cellular response to heat
GO:0043335 protein unfolding
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009368 endopeptidase Clp complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6w23, PDBe:6w23, PDBj:6w23
PDBsum6w23
PubMed32313240
UniProtP0ABH9|CLPA_ECOLI ATP-dependent Clp protease ATP-binding subunit ClpA (Gene Name=clpA)

[Back to BioLiP]