Structure of PDB 6vro Chain A Binding Site BS01

Receptor Information
>6vro Chain A (length=319) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPPADQEKLFIQKLRQCCVLFSDLKWKEVKRAALSEMVEYITHNRNVITE
PIYPEVVHMFAVNMFRTLTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKK
YIDQKFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNI
FYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIFLLKVLLPLHKV
KSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNE
LEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMS
LISDNAAKILPIMFPSLYR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6vro A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment.
Resolution2.45 Å
Binding residue
(original residue number in PDB)		K183 H187 Y190 L194 R197 R201 E226 S230 N233 G234 F235 A236 K240 H243 P265 Q266
Binding residue
(residue number reindexed from 1)		K126 H130 Y133 L137 R140 R144 E169 S173 N176 G177 F178 A179 K183 H186 P208 Q209
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0019888 protein phosphatase regulator activity
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0000159 protein phosphatase type 2A complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6vro, PDBe:6vro, PDBj:6vro
PDBsum6vro
PubMed32195664
UniProtQ13362|2A5G_HUMAN Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (Gene Name=PPP2R5C)

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