Structure of PDB 6vr7 Chain A Binding Site BS01

Receptor Information
>6vr7 Chain A (length=485) Species: 2180 (Methanothermus fervidus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NKKIVVIGGCGTVGSLMARILKSKGNDVTVSDIRKDTYLKDIFKSEGIKL
DLGGHDLSLIKKADAIAIAPSLTNNKKVLNLINKNPKAELIKIEDILKYK
VKKPVVGITGTNGKTTTREMLKNILKISGLEVPEHHLNITEFIPPLQARL
PGDVAVVEIGTFGVKNEIKRSAKNSNVTVGVITNISRDHLKNISFQEYVE
CKKEITEVAKKLVLNADDPIVASFGNDNTVYYGIENLKIKIKHFFEDRDC
PFCGKNLKYEEIFLGHLGKYECECGFKRPRPTVKAIDVENKKFILSIDSN
EGLVKLEYGGIFNVYNALAAAAAAFILKIDFDKIIEGLNTFKKVPGRMEK
IYKKPEIIIDYAHNVAGVKAILQTIKPKGRLIVVNTISSESGIKEDIKIA
KILSSADILIPASYSARKASKYTNTTVINVKSTEKKFKKGTLGASKFQVE
EAIKKALSYADKNDTILIIGEGGVKYGREIIEKIK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6vr7 Chain A Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6vr7 Archaeal pseudomurein and bacterial murein cell wall biosynthesis share a common evolutionary ancestry
Resolution2.5 Å
Binding residue
(original residue number in PDB)		C257 C260 C279 C281
Binding residue
(residue number reindexed from 1)		C250 C253 C272 C274
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004326 tetrahydrofolylpolyglutamate synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0016881 acid-amino acid ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0009058 biosynthetic process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:6vr7, PDBe:6vr7, PDBj:6vr7
PDBsum6vr7
PubMed
UniProtE3GXV7

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